Most sedating benzo
Binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites within the central nervous system, including the limbic system, reticular formation.
Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to chloride ions.
Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects.
It also lacks the prominent sedative effect that is associated with more typical anxiolytics.
About 20% or more of older American adults use some form of sleep aid, including prescription or over-the-counter drugs or alcohol. Over-the-counter or nonprescription medications make use of the drowsiness caused by some common medications.
Prescription drugs used specifically for improving sleeping are called sedative hypnotics.
Patients with chronic lung disease should also avoid some non-prescription sleeping aids, such as those containing doxylamine. When sleeplessness is caused by minor pain, simply taking acetaminophen (Tylenol) or a non-steroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin), can be very helpful without causing any daytime sleepiness. M." antihistamine found in combination products is simply an extra, needless chemical in these situations.
Newer short-acting non-benzodiazepines can induce sleep with fewer side effects than benzodiazepines.
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Side effects include: In general, people with angina, heart arrhythmias, glaucoma, or problems urinating should avoid these drugs.
They should not be used at the same time as medications that prevent nausea or motion sickness.